Names & Taxonomy
- Uniprot ID:
- Q9H228
- Entry Name:
- S1PR5_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)
- Gene Names:
- S1PR5 EDG8
- Gene Names Primary:
- S1PR5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 398
- Sequence:
- MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
- Cross Reference Drug Bank:
- DB08868
- Gene Ontology Go:
- integral component of membrane
plasma membrane
sphingosine-1-phosphate receptor activity
regulation of neuron differentiation - Gene Ontology Biological Process:
- regulation of neuron differentiation
- Gene Ontology Molecular Function:
- sphingosine-1-phosphate receptor activity
- Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix