Names & Taxonomy

Uniprot ID:
Q9H1V8
Entry Name:
S6A17_HUMAN
Status:
reviewed
Protein Names:
Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17)
Gene Names:
SLC6A17 NTT4
Gene Names Primary:
SLC6A17
Organism:
Homo sapiens (Human)

Structure

Length:
727
Sequence:
MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLASTPESEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane

Function

Function:
Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
Gene Ontology Go:
cell junction
integral component of plasma membrane
synaptic vesicle
synaptic vesicle membrane
amino acid transmembrane transporter activity
neurotransmitter:sodium symporter activity
alanine transport
amino acid transmembrane transport
brain development
glycine transport
leucine transport
neutral amino acid transport
proline transport
Gene Ontology Biological Process:
alanine transport
amino acid transmembrane transport
brain development
glycine transport
leucine transport
neutral amino acid transport
proline transport
Gene Ontology Molecular Function:
amino acid transmembrane transporter activity
neurotransmitter:sodium symporter activity
Gene Ontology Cellular Component:
cell junction
integral component of plasma membrane
synaptic vesicle
synaptic vesicle membrane
Keywords:
Cell junction
Complete proteome
Cytoplasmic vesicle
Disease mutation
Glycoprotein
Membrane
Mental retardation
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Symport
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
14702039 16710414 15489334 16125675 25704603