Names & Taxonomy
- Uniprot ID:
- Q9H0D6
- Entry Name:
- XRN2_HUMAN
- Status:
- reviewed
- Protein Names:
- 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)
- Gene Names:
- XRN2
- Gene Names Primary:
- XRN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 950
- Sequence:
- MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
- Catalytic Activity:
- Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.
- Gene Ontology Go:
- aggresome
membrane
nucleolus
nucleus
5'-3' exonuclease activity
5'-3' exoribonuclease activity
nuclease activity
poly(A) RNA binding
transcription termination site sequence-specific DNA binding
zinc ion binding
cell growth
DNA catabolic process, exonucleolytic
DNA-templated transcription, termination
mRNA processing
regulation of transcription, DNA-templated
RNA catabolic process
RNA metabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
RNA processing
spermatogenesis - Gene Ontology Biological Process:
- cell growth
DNA catabolic process, exonucleolytic
DNA-templated transcription, termination
mRNA processing
regulation of transcription, DNA-templated
RNA catabolic process
RNA metabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
RNA processing
spermatogenesis - Gene Ontology Molecular Function:
- 5'-3' exonuclease activity
5'-3' exoribonuclease activity
nuclease activity
poly(A) RNA binding
transcription termination site sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- aggresome
membrane
nucleolus
nucleus - Keywords:
- Acetylation
Alternative splicing
Complete proteome
DNA-binding
Exonuclease
Hydrolase
Metal-binding
Nuclease
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Transcription termination
Zinc
Zinc-finger
mRNA processing