Names & Taxonomy
- Uniprot ID:
- Q9C0D9
- Entry Name:
- EPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI)
- Gene Names:
- EPT1 KIAA1724 SELI
- Gene Names Primary:
- EPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 397
- Sequence:
- MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFRSYKNNTLKLNSVYEAMVPLFSPCLLFILSTAWILWSPSDILELHPRVFYFMVGTAFANSTCQLIVCQMSSTRCPTLNWLLVPLFLVVLVVNLGVASYVESILLYTLTTAFTLAHIHYGVRVVKQLSSHFQIYPFSLRKPNSDULGMEEKNIGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.
- Pathway:
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
- Catalytic Activity:
- CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.8 uM for CDP-ethanolamine
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
ethanolaminephosphotransferase activity
metal ion binding
glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process - Gene Ontology Molecular Function:
- ethanolaminephosphotransferase activity
metal ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acetylation
Complete proteome
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Selenocysteine
Transferase
Transmembrane
Transmembrane helix