Names & Taxonomy
- Uniprot ID:
- Q9BZX2
- Entry Name:
- UCK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)
- Gene Names:
- UCK2 UMPK
- Gene Names Primary:
- UCK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNGCLNGYTPSRKRQASESSSRPH
- Proteomes:
- UP000005640
Function
- Function:
- Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
- Pathway:
- Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
- Catalytic Activity:
- ATP + uridine = ADP + UMP.; ATP + cytidine = ADP + CMP.
- Gene Ontology Go:
- cytosol
ATP binding
nucleoside kinase activity
uridine kinase activity
CMP salvage
CTP salvage
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage - Gene Ontology Biological Process:
- CMP salvage
CTP salvage
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage - Gene Ontology Molecular Function:
- ATP binding
nucleoside kinase activity
uridine kinase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase