Names & Taxonomy

Uniprot ID:
Q9BZX2
Entry Name:
UCK2_HUMAN
Status:
reviewed
Protein Names:
Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)
Gene Names:
UCK2 UMPK
Gene Names Primary:
UCK2
Organism:
Homo sapiens (Human)

Structure

Length:
261
Sequence:
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNGCLNGYTPSRKRQASESSSRPH
Proteomes:
UP000005640

Function

Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Pathway:
Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
Catalytic Activity:
ATP + uridine = ADP + UMP.; ATP + cytidine = ADP + CMP.
Gene Ontology Go:
cytosol
ATP binding
nucleoside kinase activity
uridine kinase activity
CMP salvage
CTP salvage
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage
Gene Ontology Biological Process:
CMP salvage
CTP salvage
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
UMP salvage
Gene Ontology Molecular Function:
ATP binding
nucleoside kinase activity
uridine kinase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

Publication

PubMed ID:
8812458 11306702 16710414 15489334 11494055 18691976 19413330 21269460 21406692 15130468 15735337