Names & Taxonomy
- Uniprot ID:
- Q9BYE9
- Entry Name:
- CDHR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24)
- Gene Names:
- CDHR2 PCDH24 PCLKC
- Gene Names Primary:
- CDHR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1310
- Sequence:
- MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).
- Gene Ontology Go:
- apical plasma membrane
brush border
brush border membrane
cell junction
extracellular exosome
microvillus membrane
spanning component of plasma membrane
calcium ion binding
cell adhesion molecule binding
cell-cell adhesion mediated by cadherin
epithelial cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
intermicrovillar adhesion
negative regulation of cell growth involved in contact inhibition
regulation of microvillus length - Gene Ontology Biological Process:
- cell-cell adhesion mediated by cadherin
epithelial cell differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
intermicrovillar adhesion
negative regulation of cell growth involved in contact inhibition
regulation of microvillus length - Gene Ontology Molecular Function:
- calcium ion binding
cell adhesion molecule binding - Gene Ontology Cellular Component:
- apical plasma membrane
brush border
brush border membrane
cell junction
extracellular exosome
microvillus membrane
spanning component of plasma membrane - Keywords:
- Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Differentiation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9HBB8-1; Q9HBB8-2; Q6P0Q8; Q6PIF6; Q9Y6N9-1