Names & Taxonomy
- Uniprot ID:
- Q9BY07
- Entry Name:
- S4A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5)
- Gene Names:
- SLC4A5 NBC4
- Gene Names Primary:
- SLC4A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1137
- Sequence:
- MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
- Enzyme Regulation:
- ENZYME REGULATION: Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).
- Cross Reference Drug Bank:
- DB01390
- Gene Ontology Go:
- apical plasma membrane
integral component of membrane
plasma membrane
anion transmembrane transporter activity
inorganic anion exchanger activity
sodium:bicarbonate symporter activity
anion transmembrane transport
bicarbonate transport
cerebrospinal fluid secretion
epithelial cell development
ion transport
mitochondrion distribution
regulation of gene expression
regulation of systemic arterial blood pressure
renal system process
retina development in camera-type eye
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- anion transmembrane transport
bicarbonate transport
cerebrospinal fluid secretion
epithelial cell development
ion transport
mitochondrion distribution
regulation of gene expression
regulation of systemic arterial blood pressure
renal system process
retina development in camera-type eye
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- anion transmembrane transporter activity
inorganic anion exchanger activity
sodium:bicarbonate symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Anion exchange
Cell membrane
Complete proteome
Disulfide bond
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport