Names & Taxonomy
- Uniprot ID:
- Q9BX95
- Entry Name:
- SGPP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)
- Gene Names:
- SGPP1
- Gene Names Primary:
- SGPP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 441
- Sequence:
- MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
sphingosine-1-phosphate phosphatase activity
extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway
small molecule metabolic process
sphinganine-1-phosphate metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingosine metabolic process - Gene Ontology Biological Process:
- extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway
small molecule metabolic process
sphinganine-1-phosphate metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingosine metabolic process - Gene Ontology Molecular Function:
- sphingosine-1-phosphate phosphatase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
Hydrolase
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix