Names & Taxonomy
- Uniprot ID:
- Q9BVJ7
- Entry Name:
- DUS23_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)
- Gene Names:
- DUSP23 LDP3 VHZ
- Gene Names Primary:
- DUSP23
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 150
- Sequence:
- MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
Function
- Function:
- Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate
- Active Site:
- ACT_SITE 95 95 Phosphocysteine intermediate.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
peptidyl-tyrosine dephosphorylation - Gene Ontology Biological Process:
- peptidyl-tyrosine dephosphorylation
- Gene Ontology Molecular Function:
- protein serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Polymorphism
Protein phosphatase
Reference proteome - Interacts With:
- Q96B26; Q9GZT8