Names & Taxonomy
- Uniprot ID:
- Q9BV57
- Entry Name:
- MTND_HUMAN
- Status:
- reviewed
- Protein Names:
- 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L)
- Gene Names:
- ADI1 MTCBP1 HMFT1638
- Gene Names Orf:
- HMFT1638
- Gene Names Primary:
- ADI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 179
- Sequence:
- MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Function
- Function:
- Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
- Pathway:
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
- Catalytic Activity:
- 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate.
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
plasma membrane
acireductone dioxygenase activity
metal ion binding
oxidoreductase activity
cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- acireductone dioxygenase activity
metal ion binding
oxidoreductase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Amino-acid biosynthesis
Cell membrane
Complete proteome
Cytoplasm
Dioxygenase
Direct protein sequencing
Iron
Membrane
Metal-binding
Methionine biosynthesis
Nucleus
Oxidoreductase
Reference proteome - Interacts With:
- P50281