Names & Taxonomy
- Uniprot ID:
- Q9BQB6
- Entry Name:
- VKOR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)
- Gene Names:
- VKORC1 VKOR MSTP134 MSTP576 UNQ308/PRO351
- Gene Names Orf:
- MSTP134 MSTP576 UNQ308/PRO351
- Gene Names Primary:
- VKORC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 163
- Sequence:
- MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
- Catalytic Activity:
- Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by warfarin (coumadin).
- Cross Reference Drug Bank:
- DB01418 DB00266 DB00170 DB00498 DB00946 DB00682
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
blood coagulation
bone development
drug metabolic process
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- blood coagulation
bone development
drug metabolic process
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Membrane
Oxidoreductase
Quinone
Redox-active center
Reference proteome
Transmembrane
Transmembrane helix