Names & Taxonomy
- Uniprot ID:
- Q99933
- Entry Name:
- BAG1_HUMAN
- Status:
- reviewed
- Protein Names:
- BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)
- Gene Names:
- BAG1 HAP
- Gene Names Primary:
- BAG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 345
- Sequence:
- MAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSGRPPARSTASGHDRPTRGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQEVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.; Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
Function
- Function:
- Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
receptor signaling protein activity
apoptotic process
cell surface receptor signaling pathway
cellular response to heat
chaperone cofactor-dependent protein refolding
negative regulation of apoptotic process
regulation of cellular response to heat - Gene Ontology Biological Process:
- apoptotic process
cell surface receptor signaling pathway
cellular response to heat
chaperone cofactor-dependent protein refolding
negative regulation of apoptotic process
regulation of cellular response to heat - Gene Ontology Molecular Function:
- receptor signaling protein activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus - Keywords:
- 3D-structure
Alternative initiation
Alternative splicing
Apoptosis
Chaperone
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation - Interacts With:
- Q53FC7; Q96BE0; P11142; Q96IS6; Q13200; Q9UNE7; P36406; P14373