Names & Taxonomy
- Uniprot ID:
- Q99884
- Entry Name:
- SC6A7_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent proline transporter (Solute carrier family 6 member 7)
- Gene Names:
- SLC6A7 PROT
- Gene Names Primary:
- SLC6A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 636
- Sequence:
- MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
L-proline transmembrane transporter activity
neurotransmitter:sodium symporter activity
proline transport
transmembrane transport
transport - Gene Ontology Biological Process:
- proline transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- L-proline transmembrane transporter activity
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Amino-acid transport
Complete proteome
Glycoprotein
Membrane
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport