Names & Taxonomy

Uniprot ID:
Q99679
Entry Name:
GPR21_HUMAN
Status:
reviewed
Protein Names:
Probable G-protein coupled receptor 21
Gene Names:
GPR21
Gene Names Primary:
GPR21
Organism:
Homo sapiens (Human)

Structure

Length:
349
Sequence:
MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Orphan receptor.
Gene Ontology Go:
integral component of plasma membrane
dopamine binding
dopamine neurotransmitter receptor activity, coupled via Gs
G-protein coupled receptor activity
adenylate cyclase-activating dopamine receptor signaling pathway
G-protein coupled receptor signaling pathway
glucose homeostasis
learning
negative regulation of insulin receptor signaling pathway
phospholipase C-activating dopamine receptor signaling pathway
positive regulation of multicellular organism growth
synaptic transmission, dopaminergic
Gene Ontology Biological Process:
adenylate cyclase-activating dopamine receptor signaling pathway
glucose homeostasis
G-protein coupled receptor signaling pathway
learning
negative regulation of insulin receptor signaling pathway
phospholipase C-activating dopamine receptor signaling pathway
positive regulation of multicellular organism growth
synaptic transmission, dopaminergic
Gene Ontology Molecular Function:
dopamine binding
dopamine neurotransmitter receptor activity, coupled via Gs
G-protein coupled receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
Keywords:
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9073069 14702039 15489334