Names & Taxonomy
- Uniprot ID:
- Q99624
- Entry Name:
- S38A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)
- Gene Names:
- SLC38A3 G17 NAT1 SN1 SNAT3
- Gene Names Primary:
- SLC38A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 504
- Sequence:
- MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFLLMTMSLSFIIIDWASGTSRHGGNH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
- Cross Reference Drug Bank:
- DB00174 DB00130 DB00117
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane
antiporter activity
L-alanine transmembrane transporter activity
L-asparagine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-histidine transmembrane transporter activity
symporter activity
amino acid transport
asparagine transport
brain development
cellular response to potassium ion starvation
female pregnancy
glutamine transport
histidine transport
ion transport
L-alanine transport
L-histidine transmembrane transport
positive regulation of glutamine transport
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
sodium ion transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
asparagine transport
brain development
cellular response to potassium ion starvation
female pregnancy
glutamine transport
histidine transport
ion transport
L-alanine transport
L-histidine transmembrane transport
positive regulation of glutamine transport
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- antiporter activity
L-alanine transmembrane transporter activity
L-asparagine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-histidine transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Amino-acid transport
Antiport
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport