Names & Taxonomy

Uniprot ID:
Q99519
Entry Name:
NEUR1_HUMAN
Status:
reviewed
Protein Names:
Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)
Gene Names:
NEU1 NANH
Gene Names Primary:
NEU1
Organism:
Homo sapiens (Human)

Structure

Length:
415
Sequence:
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.

Function

Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Catalytic Activity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Active Site:
ACT_SITE 103 103 Proton acceptor.
Cross Reference Drug Bank:
DB00198
Gene Ontology Go:
cell junction
cell surface
cytoplasmic, membrane-bounded vesicle
extracellular exosome
intracellular membrane-bounded organelle
lysosomal lumen
lysosomal membrane
lysosome
membrane
plasma membrane
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
exo-alpha-sialidase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of neuron projection development
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of myoblast proliferation
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Biological Process:
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of neuron projection development
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of myoblast proliferation
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Molecular Function:
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
exo-alpha-sialidase activity
Gene Ontology Cellular Component:
cell junction
cell surface
cytoplasmic, membrane-bounded vesicle
extracellular exosome
intracellular membrane-bounded organelle
lysosomal lumen
lysosomal membrane
lysosome
membrane
plasma membrane
Keywords:
Carbohydrate metabolism
Cell membrane
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Glycoprotein
Glycosidase
Hydrolase
Lipid degradation
Lipid metabolism
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal

Publication

PubMed ID:
8985184 9020182 9054950 14656967 15489334 9480870 11571282 19159218 21269460 10767332 11063730 10944856 11279074 11829139 14695530