Names & Taxonomy
- Uniprot ID:
- Q99519
- Entry Name:
- NEUR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)
- Gene Names:
- NEU1 NANH
- Gene Names Primary:
- NEU1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 415
- Sequence:
- MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Function
- Function:
- Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
- Catalytic Activity:
- Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
- Active Site:
- ACT_SITE 103 103 Proton acceptor.
- Cross Reference Drug Bank:
- DB00198
- Gene Ontology Go:
- cell junction
cell surface
cytoplasmic, membrane-bounded vesicle
extracellular exosome
intracellular membrane-bounded organelle
lysosomal lumen
lysosomal membrane
lysosome
membrane
plasma membrane
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
exo-alpha-sialidase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of neuron projection development
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of myoblast proliferation
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of neuron projection development
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of myoblast proliferation
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
exo-alpha-sialidase activity - Gene Ontology Cellular Component:
- cell junction
cell surface
cytoplasmic, membrane-bounded vesicle
extracellular exosome
intracellular membrane-bounded organelle
lysosomal lumen
lysosomal membrane
lysosome
membrane
plasma membrane - Keywords:
- Carbohydrate metabolism
Cell membrane
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Glycoprotein
Glycosidase
Hydrolase
Lipid degradation
Lipid metabolism
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal