Names & Taxonomy
- Uniprot ID:
- Q96S37
- Entry Name:
- S22AC_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1)
- Gene Names:
- SLC22A12 OATL4 URAT1 UNQ6453/PRO34004
- Gene Names Orf:
- UNQ6453/PRO34004
- Gene Names Primary:
- SLC22A12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 553
- Sequence:
- MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.
- Cross Reference Drug Bank:
- DB00678 DB01032
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
inorganic anion exchanger activity
PDZ domain binding
sodium-independent organic anion transmembrane transporter activity
urate transmembrane transporter activity
anion transmembrane transport
cellular homeostasis
organic acid transmembrane transport
response to drug
sodium-independent organic anion transport
transmembrane transport
urate metabolic process
urate transport - Gene Ontology Biological Process:
- anion transmembrane transport
cellular homeostasis
organic acid transmembrane transport
response to drug
sodium-independent organic anion transport
transmembrane transport
urate metabolic process
urate transport - Gene Ontology Molecular Function:
- inorganic anion exchanger activity
PDZ domain binding
sodium-independent organic anion transmembrane transporter activity
urate transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport