Names & Taxonomy

Uniprot ID:
Q96S37
Entry Name:
S22AC_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1)
Gene Names:
SLC22A12 OATL4 URAT1 UNQ6453/PRO34004
Gene Names Orf:
UNQ6453/PRO34004
Gene Names Primary:
SLC22A12
Organism:
Homo sapiens (Human)

Structure

Length:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.
Cross Reference Drug Bank:
DB00678 DB01032
Gene Ontology Go:
apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
inorganic anion exchanger activity
PDZ domain binding
sodium-independent organic anion transmembrane transporter activity
urate transmembrane transporter activity
anion transmembrane transport
cellular homeostasis
organic acid transmembrane transport
response to drug
sodium-independent organic anion transport
transmembrane transport
urate metabolic process
urate transport
Gene Ontology Biological Process:
anion transmembrane transport
cellular homeostasis
organic acid transmembrane transport
response to drug
sodium-independent organic anion transport
transmembrane transport
urate metabolic process
urate transport
Gene Ontology Molecular Function:
inorganic anion exchanger activity
PDZ domain binding
sodium-independent organic anion transmembrane transporter activity
urate transmembrane transporter activity
Gene Ontology Cellular Component:
apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12024214 12975309 14702039 16554811 15489334 16837472 14531806 15304510 14694169 15327384 15634722 15912381 16385546 26418379