Names & Taxonomy

Uniprot ID:
Q96RJ0
Entry Name:
TAAR1_HUMAN
Status:
reviewed
Protein Names:
Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
Gene Names:
TAAR1 TA1 TAR1 TRAR1
Gene Names Primary:
TAAR1
Organism:
Homo sapiens (Human)

Structure

Length:
339
Sequence:
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Cross Reference Drug Bank:
DB00182 DB01576 DB01577 DB06714
Gene Ontology Go:
integral component of membrane
plasma membrane
G-protein coupled receptor activity
trace-amine receptor activity
cAMP biosynthetic process
G-protein coupled receptor signaling pathway
Gene Ontology Biological Process:
cAMP biosynthetic process
G-protein coupled receptor signaling pathway
Gene Ontology Molecular Function:
G-protein coupled receptor activity
trace-amine receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11459929 11723224 14574404 15489334 15718104