Names & Taxonomy
- Uniprot ID:
- Q96RJ0
- Entry Name:
- TAAR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
- Gene Names:
- TAAR1 TA1 TAR1 TRAR1
- Gene Names Primary:
- TAAR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 339
- Sequence:
- MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
- Cross Reference Drug Bank:
- DB00182 DB01576 DB01577 DB06714
- Gene Ontology Go:
- integral component of membrane
plasma membrane
G-protein coupled receptor activity
trace-amine receptor activity
cAMP biosynthetic process
G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- cAMP biosynthetic process
G-protein coupled receptor signaling pathway - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
trace-amine receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix