Names & Taxonomy
- Uniprot ID:
- Q96NX5
- Entry Name:
- KCC1G_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
- Gene Names:
- CAMK1G CLICK3 VWS1
- Gene Names Primary:
- CAMK1G
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCSSCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1 (By similarity).
- Active Site:
- ACT_SITE 143 143 Proton acceptor.
- Gene Ontology Go:
- calcium- and calmodulin-dependent protein kinase complex
Golgi membrane
neuron projection
plasma membrane
ATP binding
calmodulin-dependent protein kinase activity - Gene Ontology Molecular Function:
- ATP binding
calmodulin-dependent protein kinase activity - Gene Ontology Cellular Component:
- calcium- and calmodulin-dependent protein kinase complex
Golgi membrane
neuron projection
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Allosteric enzyme
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Cytoplasm
Golgi apparatus
Kinase
Lipoprotein
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Prenylation
Reference proteome
Serine/threonine-protein kinase
Transferase