Names & Taxonomy
- Uniprot ID:
- Q96LT4
- Entry Name:
- SAMD8_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8)
- Gene Names:
- SAMD8
- Gene Names Primary:
- SAMD8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 415
- Sequence:
- MAGPNQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHIDVLEEMGYNSDSPMGSMTPFISALQSTDWLCNGELSHDCDGPITDLNSDQYQYMNGKNKHSVRRLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYQQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
- Active Site:
- ACT_SITE 301 301
- Gene Ontology Go:
- integral component of endoplasmic reticulum membrane
integral component of membrane
transferase activity
ceramide biosynthetic process
regulation of ceramide biosynthetic process
sphingomyelin biosynthetic process - Gene Ontology Biological Process:
- ceramide biosynthetic process
regulation of ceramide biosynthetic process
sphingomyelin biosynthetic process - Gene Ontology Molecular Function:
- transferase activity
- Gene Ontology Cellular Component:
- integral component of endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Lipid metabolism
Membrane
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane
Transmembrane helix