Names & Taxonomy
- Uniprot ID:
- Q96I99
- Entry Name:
- SUCB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)
- Gene Names:
- SUCLG2
- Gene Names Primary:
- SUCLG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 432
- Sequence:
- MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle.
- Catalytic Activity:
- GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- microtubule organizing center
mitochondrial matrix
mitochondrion
nucleus
plasma membrane
ATP binding
GTP binding
succinate-CoA ligase (GDP-forming) activity
cellular metabolic process
small molecule metabolic process
succinyl-CoA metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
small molecule metabolic process
succinyl-CoA metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- ATP binding
GTP binding
succinate-CoA ligase (GDP-forming) activity - Gene Ontology Cellular Component:
- microtubule organizing center
mitochondrial matrix
mitochondrion
nucleus
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
GTP-binding
Ligase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Tricarboxylic acid cycle