Names & Taxonomy
- Uniprot ID:
- Q96GD3
- Entry Name:
- SCMH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Polycomb protein SCMH1 (Sex comb on midleg homolog 1)
- Gene Names:
- SCMH1
- Gene Names Primary:
- SCMH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 660
- Sequence:
- MLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKTLISHPISAPSKTAEPLKFPKKRGPKPGSKRKPRTLLNPPPASPTTSTPEPDTSTVPQDAATIPSSAMQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTAIEYSHSHDRYLPGETFVLGNSLARSLEPHSDSMDSASNPTNLVSTSQRHRPLLSSCGLPPSTASAVRRLCSRGVLKGSNERRDMESFWKLNRSPGSDRYLESRDASRLSGRDPSSWTVEDVMQFVREADPQLGPHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSYHIDRLKQGKF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.
- Gene Ontology Go:
- chromocenter
nucleoplasm
nucleus
DNA binding
transcription factor activity, sequence-specific DNA binding
anatomical structure morphogenesis
anterior/posterior pattern specification
cellular protein metabolic process
chromatin remodeling
gene silencing
negative regulation of transcription, DNA-templated
post-translational protein modification
protein sumoylation
spermatogenesis
transcription, DNA-templated - Gene Ontology Biological Process:
- anatomical structure morphogenesis
anterior/posterior pattern specification
cellular protein metabolic process
chromatin remodeling
gene silencing
negative regulation of transcription, DNA-templated
post-translational protein modification
protein sumoylation
spermatogenesis
transcription, DNA-templated - Gene Ontology Molecular Function:
- DNA binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- chromocenter
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Developmental protein
Nucleus
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation - Interacts With:
- Q6FHH8; Q9UMX0; Q9UMX0-2