Names & Taxonomy
- Uniprot ID:
- Q96FL8
- Entry Name:
- S47A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
- Gene Names:
- SLC47A1 MATE1
- Gene Names Primary:
- SLC47A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 570
- Sequence:
- MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.38 mM for TEA
- Cross Reference Drug Bank:
- DB00787 DB01237 DB00567 DB00501 DB00199 DB00331 DB00877
- Gene Ontology Go:
- integral component of membrane
membrane-bounded vesicle
plasma membrane
drug transmembrane transporter activity
monovalent cation:proton antiporter activity
drug transmembrane transport
organic cation transport
transmembrane transport - Gene Ontology Biological Process:
- drug transmembrane transport
organic cation transport
transmembrane transport - Gene Ontology Molecular Function:
- drug transmembrane transporter activity
monovalent cation:proton antiporter activity - Gene Ontology Cellular Component:
- integral component of membrane
membrane-bounded vesicle
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Cell membrane
Complete proteome
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport