Names & Taxonomy
- Uniprot ID:
- Q96DP5
- Entry Name:
- FMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)
- Gene Names:
- MTFMT FMT FMT1
- Gene Names Primary:
- MTFMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 389
- Sequence:
- MRVLVRRCWGPPLAHGARRGRPSPQWRALARLGWEDCRDSRVREKPPWRVLFFGTDQFAREALRALHAARENKEEELIDKLEVVTMPSPSPKGLPVKQYAVQSQLPVYEWPDVGSGEYDVGVVASFGRLLNEALILKFPYGILNVHPSCLPRWRGPAPVIHTVLHGDTVTGVTIMQIRPKRFDVGPILKQETVPVPPKSTAKELEAVLSRLGANMLISVLKNLPESLSNGRQQPMEGATYAPKISAGTSCIKWEEQTSEQIFRLYRAIGNIIPLQTLWMANTIKLLDLVEVNSSVLADPKLTGQALIPGSVIYHKQSQILLVYCKDGWIGVRSVMLKKSLTATDFYNGYLHPWYQKNSQAQPSQCRFQTLRLPTKKKQKKTVAMQQCIE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).
- Catalytic Activity:
- 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- mitochondrion
methionyl-tRNA formyltransferase activity
mitochondrial translation
mitochondrial translational initiation
organelle organization - Gene Ontology Biological Process:
- mitochondrial translation
mitochondrial translational initiation
organelle organization - Gene Ontology Molecular Function:
- methionyl-tRNA formyltransferase activity
- Gene Ontology Cellular Component:
- mitochondrion
- Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Leigh syndrome
Mitochondrion
Polymorphism
Protein biosynthesis
Reference proteome
Transferase
Transit peptide