Names & Taxonomy
- Uniprot ID:
- Q96C24
- Entry Name:
- SYTL4_HUMAN
- Status:
- reviewed
- Protein Names:
- Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
- Gene Names:
- SYTL4
- Gene Names Primary:
- SYTL4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 671
- Sequence:
- MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- apical plasma membrane
centrosome
cytoplasm
endosome
exocytic vesicle
extrinsic component of membrane
nucleoplasm
secretory granule membrane
transport vesicle membrane
calcium ion binding
calcium-dependent phospholipid binding
clathrin binding
neurexin family protein binding
phospholipid binding
syntaxin binding
zinc ion binding
exocytosis
intracellular protein transport
multivesicular body sorting pathway
negative regulation of insulin secretion
positive regulation of exocytosis
positive regulation of protein secretion - Gene Ontology Biological Process:
- exocytosis
intracellular protein transport
multivesicular body sorting pathway
negative regulation of insulin secretion
positive regulation of exocytosis
positive regulation of protein secretion - Gene Ontology Molecular Function:
- calcium-dependent phospholipid binding
calcium ion binding
clathrin binding
neurexin family protein binding
phospholipid binding
syntaxin binding
zinc ion binding - Gene Ontology Cellular Component:
- apical plasma membrane
centrosome
cytoplasm
endosome
exocytic vesicle
extrinsic component of membrane
nucleoplasm
secretory granule membrane
transport vesicle membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Zinc
Zinc-finger - Interacts With:
- Q8NHQ1; P51116; Q9NP66; O15156