Names & Taxonomy

Uniprot ID:
Q96C24
Entry Name:
SYTL4_HUMAN
Status:
reviewed
Protein Names:
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene Names:
SYTL4
Gene Names Primary:
SYTL4
Organism:
Homo sapiens (Human)

Structure

Length:
671
Sequence:
MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
Cross Reference Drug Bank:
DB00030
Gene Ontology Go:
apical plasma membrane
centrosome
cytoplasm
endosome
exocytic vesicle
extrinsic component of membrane
nucleoplasm
secretory granule membrane
transport vesicle membrane
calcium ion binding
calcium-dependent phospholipid binding
clathrin binding
neurexin family protein binding
phospholipid binding
syntaxin binding
zinc ion binding
exocytosis
intracellular protein transport
multivesicular body sorting pathway
negative regulation of insulin secretion
positive regulation of exocytosis
positive regulation of protein secretion
Gene Ontology Biological Process:
exocytosis
intracellular protein transport
multivesicular body sorting pathway
negative regulation of insulin secretion
positive regulation of exocytosis
positive regulation of protein secretion
Gene Ontology Molecular Function:
calcium-dependent phospholipid binding
calcium ion binding
clathrin binding
neurexin family protein binding
phospholipid binding
syntaxin binding
zinc ion binding
Gene Ontology Cellular Component:
apical plasma membrane
centrosome
cytoplasm
endosome
exocytic vesicle
extrinsic component of membrane
nucleoplasm
secretory granule membrane
transport vesicle membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Zinc
Zinc-finger
Interacts With:
Q8NHQ1; P51116; Q9NP66; O15156

Publication

PubMed ID:
14702039 17974005 15772651 15489334 17081983 18088087 18669648 24275569