Names & Taxonomy
- Uniprot ID:
- Q969V6
- Entry Name:
- MKL1_HUMAN
- Status:
- reviewed
- Protein Names:
- MKL/myocardin-like protein 1 (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) (Myocardin-related transcription factor A) (MRTF-A)
- Gene Names:
- MKL1 KIAA1438 MAL
- Gene Names Primary:
- MKL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 931
- Sequence:
- MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
actin binding
actin monomer binding
leucine zipper domain binding
RNA polymerase II transcription coactivator activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
negative regulation of apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription via serum response element binding
small GTPase mediated signal transduction
smooth muscle cell differentiation - Gene Ontology Biological Process:
- negative regulation of apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription via serum response element binding
small GTPase mediated signal transduction
smooth muscle cell differentiation - Gene Ontology Molecular Function:
- actin binding
actin monomer binding
leucine zipper domain binding
RNA polymerase II transcription coactivator activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus - Keywords:
- 3D-structure
Actin-binding
Chromosomal rearrangement
Coiled coil
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Repeat
Transcription
Transcription regulation - Interacts With:
- P11831