Names & Taxonomy

Uniprot ID:
Q92993
Entry Name:
KAT5_HUMAN
Status:
reviewed
Protein Names:
Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (cPLA(2)-interacting protein)
Gene Names:
KAT5 HTATIP TIP60
Gene Names Primary:
KAT5
Organism:
Homo sapiens (Human)

Structure

Length:
513
Sequence:
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).
Catalytic Activity:
Acetyl-CoA + = CoA + acetyl-.
Active Site:
ACT_SITE 403 403 Proton donor/acceptor.
Gene Ontology Go:
NuA4 histone acetyltransferase complex
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
Piccolo NuA4 histone acetyltransferase complex
Swr1 complex
transcription factor complex
acetyltransferase activity
androgen receptor binding
histone acetyltransferase activity
metal ion binding
repressing transcription factor binding
transcription coactivator activity
androgen receptor signaling pathway
cellular response to estradiol stimulus
chromatin organization
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
double-strand break repair via synthesis-dependent strand annealing
histone acetylation
negative regulation of interleukin-2 production
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of protein acetylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of growth
response to ionizing radiation
transcription, DNA-templated
viral process
Gene Ontology Biological Process:
androgen receptor signaling pathway
cellular response to estradiol stimulus
chromatin organization
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
double-strand break repair via synthesis-dependent strand annealing
histone acetylation
negative regulation of interleukin-2 production
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein acetylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of growth
response to ionizing radiation
transcription, DNA-templated
viral process
Gene Ontology Molecular Function:
acetyltransferase activity
androgen receptor binding
histone acetyltransferase activity
metal ion binding
repressing transcription factor binding
transcription coactivator activity
Gene Ontology Cellular Component:
NuA4 histone acetyltransferase complex
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
Piccolo NuA4 histone acetyltransferase complex
Swr1 complex
transcription factor complex
Keywords:
3D-structure
Acetylation
Activator
Acyltransferase
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Direct protein sequencing
Growth regulation
Host-virus interaction
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Transferase
Ubl conjugation
Zinc
Zinc-finger
Interacts With:
P54253; Q9HC52; Q96JN2-2; Q9P2H0; O43261; Q53SE7; Q9BZS1-1; O95257; Q8NEA9; Q08379; Q6NT76; Q9UKT9; Q6A162; P60411; Q17RB8; Q9BRK4; Q99750; A4D127; Q5JR59; P10085; Q9Y2I6; Q9HC29; P11926; Q8IXK0; Q9NQM4; P29074; P35711; Q01130; Q9Y2D8; O75558; Q7Z6C6; P04637; P36406; P14373; O94972; Q9NNX1; Q15672; O43829; Q96BR9; Q8N8E2

Publication

PubMed ID:
8607265 11416127 12801643 14702039 16554811 15489334 12963728 10096020 10966108 11262386 11927554 12776177 12468530 12551922 15196461 15310756 15502158 14966270 15121871 15042092 16001085 16141325 16835243 16387653 17360565 17996965 18451177 18397884 17704809 18669648 19909775 19690332 19608861 25245946 24463511