Names & Taxonomy
- Uniprot ID:
- Q92959
- Entry Name:
- SO2A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)
- Gene Names:
- SLCO2A1 OATP2A1 SLC21A2
- Gene Names Primary:
- SLCO2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 643
- Sequence:
- MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.
- Cross Reference Drug Bank:
- DB00770 DB01160 DB00917 DB00695 DB01088 DB04398 DB01174 DB00119
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
lipid transporter activity
prostaglandin transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
lipid transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- lipid transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- lipid transporter activity
prostaglandin transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P62993