Names & Taxonomy

Uniprot ID:
Q92952
Entry Name:
KCNN1_HUMAN
Status:
reviewed
Protein Names:
Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1)
Gene Names:
KCNN1 SK
Gene Names Primary:
KCNN1
Organism:
Homo sapiens (Human)

Structure

Length:
543
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 317 337 Pore-forming; Name=Segment H5.

Function

Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Cross Reference Drug Bank:
DB01110 DB00721
Gene Ontology Go:
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
calmodulin binding
small conductance calcium-activated potassium channel activity
potassium ion transport
synaptic transmission
Gene Ontology Biological Process:
potassium ion transport
synaptic transmission
Gene Ontology Molecular Function:
calcium-activated potassium channel activity
calmodulin binding
small conductance calcium-activated potassium channel activity
Gene Ontology Cellular Component:
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8781233 10516439 15489334