Names & Taxonomy
- Uniprot ID:
- Q92952
- Entry Name:
- KCNN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1)
- Gene Names:
- KCNN1 SK
- Gene Names Primary:
- KCNN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 543
- Sequence:
- MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 317 337 Pore-forming; Name=Segment H5.
Function
- Function:
- Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
- Cross Reference Drug Bank:
- DB01110 DB00721
- Gene Ontology Go:
- neuronal cell body
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
calmodulin binding
small conductance calcium-activated potassium channel activity
potassium ion transport
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transport
synaptic transmission - Gene Ontology Molecular Function:
- calcium-activated potassium channel activity
calmodulin binding
small conductance calcium-activated potassium channel activity - Gene Ontology Cellular Component:
- neuronal cell body
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport