Names & Taxonomy

Uniprot ID:
Q92930
Entry Name:
RAB8B_HUMAN
Status:
reviewed
Protein Names:
Ras-related protein Rab-8B
Gene Names:
RAB8B
Gene Names Primary:
RAB8B
Organism:
Homo sapiens (Human)

Structure

Length:
207
Sequence:
MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSANVEEAFFTLARDIMTKLNRKMNDSNSAGAGGPVKITENRSKKTSFFRCSLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).
Gene Ontology Go:
cell tip
extracellular exosome
mitochondrion
perinuclear region of cytoplasm
peroxisomal membrane
phagocytic vesicle
phagocytic vesicle membrane
plasma membrane
GDP binding
GTP binding
GTPase activity
receptor binding
adherens junction organization
antigen processing and presentation
positive regulation of cell projection organization
positive regulation of corticotropin secretion
protein import into peroxisome membrane
protein secretion
small GTPase mediated signal transduction
vesicle docking involved in exocytosis
Gene Ontology Biological Process:
adherens junction organization
antigen processing and presentation
positive regulation of cell projection organization
positive regulation of corticotropin secretion
protein import into peroxisome membrane
protein secretion
small GTPase mediated signal transduction
vesicle docking involved in exocytosis
Gene Ontology Molecular Function:
GDP binding
GTPase activity
GTP binding
receptor binding
Gene Ontology Cellular Component:
cell tip
extracellular exosome
mitochondrion
perinuclear region of cytoplasm
peroxisomal membrane
phagocytic vesicle
phagocytic vesicle membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Cytoplasmic vesicle
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Prenylation
Protein transport
Reference proteome
Transport

Publication

PubMed ID:
14702039 17974005 16572171 15489334 9030196 12221131 19690332 21269460 21255211