Names & Taxonomy

Uniprot ID:
Q92854
Entry Name:
SEM4D_HUMAN
Status:
reviewed
Protein Names:
Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)
Gene Names:
SEMA4D C9orf164 CD100 SEMAJ
Gene Names Primary:
SEMA4D
Organism:
Homo sapiens (Human)

Structure

Length:
862
Sequence:
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Gene Ontology Go:
extracellular space
integral component of plasma membrane
plasma membrane
chemorepellent activity
receptor activity
receptor binding
semaphorin receptor binding
transmembrane signaling receptor activity
axon guidance
cell adhesion
immune response
leukocyte aggregation
negative chemotaxis
negative regulation of alkaline phosphatase activity
negative regulation of apoptotic process
negative regulation of axon extension involved in axon guidance
negative regulation of cell adhesion
negative regulation of osteoblast differentiation
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
ossification involved in bone maturation
positive regulation of cell migration
positive regulation of collateral sprouting
positive regulation of GTPase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein phosphorylation
regulation of cell projection organization
regulation of cell shape
regulation of dendrite morphogenesis
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Gene Ontology Biological Process:
axon guidance
cell adhesion
immune response
leukocyte aggregation
negative chemotaxis
negative regulation of alkaline phosphatase activity
negative regulation of apoptotic process
negative regulation of axon extension involved in axon guidance
negative regulation of cell adhesion
negative regulation of osteoblast differentiation
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
ossification involved in bone maturation
positive regulation of cell migration
positive regulation of collateral sprouting
positive regulation of GTPase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein phosphorylation
regulation of cell projection organization
regulation of cell shape
regulation of dendrite morphogenesis
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Gene Ontology Molecular Function:
chemorepellent activity
receptor activity
receptor binding
semaphorin receptor binding
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
extracellular space
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Neurogenesis
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8876214 15164053 15489334 14702039 10520995 16055703 16263699 19788569 19349973 12958590 20877282