Names & Taxonomy
- Uniprot ID:
- Q92831
- Entry Name:
- KAT2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF)
- Gene Names:
- KAT2B PCAF
- Gene Names Primary:
- KAT2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 832
- Sequence:
- MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
- Catalytic Activity:
- Acetyl-CoA + = CoA + acetyl-.
- Active Site:
- ACT_SITE 570 570 Proton donor/acceptor.
- Gene Ontology Go:
- A band
actomyosin
Ada2/Gcn5/Ada3 transcription activator complex
cytosol
I band
kinetochore
nuclear chromatin
nucleoplasm
nucleus
PCAF complex
acetyltransferase activity
chromatin binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
histone acetyltransferase activity
histone deacetylase binding
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
protein complex binding
protein kinase binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcription coactivator activity
transcription cofactor activity
transcription factor binding
cell cycle arrest
cellular response to insulin stimulus
cellular response to oxidative stress
cellular response to parathyroid hormone stimulus
chromatin organization
chromatin remodeling
gene expression
histone H3 acetylation
histone H3-K9 acetylation
internal peptidyl-lysine acetylation
memory
N-terminal peptidyl-lysine acetylation
negative regulation of cell proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Notch signaling pathway
peptidyl-lysine acetylation
positive regulation of chromatin binding
positive regulation of gene expression, epigenetic
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
positive regulation of histone H3-K14 acetylation
positive regulation of histone H3-K9 acetylation
positive regulation of neuron projection development
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vasodilation
protein acetylation
regulation of gene expression, epigenetic
regulation of protein ADP-ribosylation
rhythmic process
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
transcription initiation from RNA polymerase II promoter
viral process - Gene Ontology Biological Process:
- cell cycle arrest
cellular response to insulin stimulus
cellular response to oxidative stress
cellular response to parathyroid hormone stimulus
chromatin organization
chromatin remodeling
gene expression
histone H3 acetylation
histone H3-K9 acetylation
internal peptidyl-lysine acetylation
memory
negative regulation of cell proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Notch signaling pathway
N-terminal peptidyl-lysine acetylation
peptidyl-lysine acetylation
positive regulation of chromatin binding
positive regulation of gene expression, epigenetic
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
positive regulation of histone H3-K14 acetylation
positive regulation of histone H3-K9 acetylation
positive regulation of neuron projection development
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vasodilation
protein acetylation
regulation of gene expression, epigenetic
regulation of protein ADP-ribosylation
rhythmic process
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase II promoter
transcription initiation from RNA polymerase I promoter
viral process - Gene Ontology Molecular Function:
- acetyltransferase activity
chromatin binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
histone acetyltransferase activity
histone deacetylase binding
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
protein complex binding
protein kinase binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcription coactivator activity
transcription cofactor activity
transcription factor binding - Gene Ontology Cellular Component:
- A band
actomyosin
Ada2/Gcn5/Ada3 transcription activator complex
cytosol
I band
kinetochore
nuclear chromatin
nucleoplasm
nucleus
PCAF complex - Keywords:
- 3D-structure
Activator
Acyltransferase
Biological rhythms
Bromodomain
Cell cycle
Complete proteome
Host-virus interaction
Nucleus
Polymorphism
Reference proteome
Transcription
Transcription regulation
Transferase - Interacts With:
- P03255; P03255-2; O60566; Q92793; P03129; Q96KQ7; Q09472; Q16665; P02299; P84040; Q96EB6; Q8IXJ6; Q16594; O88898-2; Q15672; P22415