Names & Taxonomy

Uniprot ID:
Q92823
Entry Name:
NRCAM_HUMAN
Status:
reviewed
Protein Names:
Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
Gene Names:
NRCAM KIAA0343
Gene Names Primary:
NRCAM
Organism:
Homo sapiens (Human)

Structure

Length:
1304
Sequence:
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Gene Ontology Go:
axon initial segment
external side of plasma membrane
extracellular region
integral component of plasma membrane
neuron projection
plasma membrane
synapse
ankyrin binding
angiogenesis
axon guidance
axonal fasciculation
axonogenesis
central nervous system development
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
neuron migration
neuronal action potential propagation
positive regulation of neuron differentiation
protein localization
regulation of axon extension
retinal ganglion cell axon guidance
single organismal cell-cell adhesion
synapse assembly
Gene Ontology Biological Process:
angiogenesis
axonal fasciculation
axon guidance
axonogenesis
central nervous system development
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
neuronal action potential propagation
neuron migration
positive regulation of neuron differentiation
protein localization
regulation of axon extension
retinal ganglion cell axon guidance
single organismal cell-cell adhesion
synapse assembly
Gene Ontology Molecular Function:
ankyrin binding
Gene Ontology Cellular Component:
axon initial segment
external side of plasma membrane
extracellular region
integral component of plasma membrane
neuron projection
plasma membrane
synapse
Keywords:
3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8812479 11483367 9205841 17974005 12853948 12690205 15489334 16335952 19159218 19139490 23897819 16959974