Names & Taxonomy
- Uniprot ID:
- Q92736
- Entry Name:
- RYR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
- Gene Names:
- RYR2
- Gene Names Primary:
- RYR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 4967
- Sequence:
- MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Sarcoplasmic reticulum membrane
- Intramembrane:
- INTRAMEM 4820 4829 Pore-forming.
Function
- Function:
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
- Gene Ontology Go:
- calcium channel complex
extracellular exosome
junctional sarcoplasmic reticulum membrane
membrane
plasma membrane
protein complex
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
smooth endoplasmic reticulum
Z disc
calcium channel activity
calcium ion binding
calcium-induced calcium release activity
calcium-release channel activity
calmodulin binding
enzyme binding
identical protein binding
ion channel binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
ryanodine-sensitive calcium-release channel activity
suramin binding
BMP signaling pathway
calcium ion transport
calcium ion transport into cytosol
calcium-mediated signaling
calcium-mediated signaling using intracellular calcium source
canonical Wnt signaling pathway
cardiac conduction
cardiac muscle contraction
cardiac muscle hypertrophy
cell communication by electrical coupling involved in cardiac conduction
cellular calcium ion homeostasis
cellular response to caffeine
cellular response to epinephrine stimulus
detection of calcium ion
embryonic heart tube morphogenesis
establishment of protein localization to endoplasmic reticulum
ion transmembrane transport
left ventricular cardiac muscle tissue morphogenesis
positive regulation of calcium-transporting ATPase activity
positive regulation of heart rate
positive regulation of sequestering of calcium ion
positive regulation of the force of heart contraction
Purkinje myocyte to ventricular cardiac muscle cell signaling
regulation of atrial cardiac muscle cell action potential
regulation of AV node cell action potential
regulation of cardiac conduction
regulation of cardiac muscle contraction
regulation of cardiac muscle contraction by calcium ion signaling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cytosolic calcium ion concentration
regulation of heart rate
regulation of SA node cell action potential
regulation of ventricular cardiac muscle cell action potential
release of sequestered calcium ion into cytosol
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to caffeine
response to hypoxia
response to muscle activity
response to muscle stretch
response to redox state
sarcoplasmic reticulum calcium ion transport
transmembrane transport
type B pancreatic cell apoptotic process
ventricular cardiac muscle cell action potential - Gene Ontology Biological Process:
- BMP signaling pathway
calcium ion transport
calcium ion transport into cytosol
calcium-mediated signaling
calcium-mediated signaling using intracellular calcium source
canonical Wnt signaling pathway
cardiac conduction
cardiac muscle contraction
cardiac muscle hypertrophy
cell communication by electrical coupling involved in cardiac conduction
cellular calcium ion homeostasis
cellular response to caffeine
cellular response to epinephrine stimulus
detection of calcium ion
embryonic heart tube morphogenesis
establishment of protein localization to endoplasmic reticulum
ion transmembrane transport
left ventricular cardiac muscle tissue morphogenesis
positive regulation of calcium-transporting ATPase activity
positive regulation of heart rate
positive regulation of sequestering of calcium ion
positive regulation of the force of heart contraction
Purkinje myocyte to ventricular cardiac muscle cell signaling
regulation of atrial cardiac muscle cell action potential
regulation of AV node cell action potential
regulation of cardiac conduction
regulation of cardiac muscle contraction
regulation of cardiac muscle contraction by calcium ion signaling
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cytosolic calcium ion concentration
regulation of heart rate
regulation of SA node cell action potential
regulation of ventricular cardiac muscle cell action potential
release of sequestered calcium ion into cytosol
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to caffeine
response to hypoxia
response to muscle activity
response to muscle stretch
response to redox state
sarcoplasmic reticulum calcium ion transport
transmembrane transport
type B pancreatic cell apoptotic process
ventricular cardiac muscle cell action potential - Gene Ontology Molecular Function:
- calcium channel activity
calcium-induced calcium release activity
calcium ion binding
calcium-release channel activity
calmodulin binding
enzyme binding
identical protein binding
ion channel binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
ryanodine-sensitive calcium-release channel activity
suramin binding - Gene Ontology Cellular Component:
- calcium channel complex
extracellular exosome
junctional sarcoplasmic reticulum membrane
membrane
plasma membrane
protein complex
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
smooth endoplasmic reticulum
Z disc - Keywords:
- 3D-structure
Alternative splicing
Calcium
Calcium channel
Calcium transport
Calmodulin-binding
Cardiomyopathy
Coiled coil
Complete proteome
Developmental protein
Disease mutation
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P62942; P68106; Q00987