Names & Taxonomy
- Uniprot ID:
- Q92673
- Entry Name:
- SORL_HUMAN
- Status:
- reviewed
- Protein Names:
- Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
- Gene Names:
- SORL1 C11orf32
- Gene Names Primary:
- SORL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2214
- Sequence:
- MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
- Gene Ontology Go:
- early endosome
endoplasmic reticulum
endosome
extracellular exosome
extracellular space
Golgi apparatus
Golgi cisterna
integral component of plasma membrane
low-density lipoprotein particle
membrane
nuclear envelope lumen
recycling endosome
trans-Golgi network
ADP-ribosylation factor binding
beta-amyloid binding
low-density lipoprotein particle binding
transmembrane signaling receptor activity
cholesterol metabolic process
lipid transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of beta-amyloid formation
negative regulation of MAP kinase activity
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of neurofibrillary tangle assembly
negative regulation of neurogenesis
negative regulation of neuron death
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of tau-protein kinase activity
positive regulation of choline O-acetyltransferase activity
positive regulation of early endosome to recycling endosome transport
positive regulation of endocytic recycling
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of protein catabolic process
positive regulation of protein exit from endoplasmic reticulum
positive regulation of protein localization to early endosome
post-Golgi vesicle-mediated transport
protein maturation
protein retention in Golgi apparatus
protein targeting
protein targeting to Golgi
protein targeting to lysosome
receptor-mediated endocytosis
regulation of smooth muscle cell migration
signal transduction - Gene Ontology Biological Process:
- cholesterol metabolic process
lipid transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of beta-amyloid formation
negative regulation of MAP kinase activity
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of neurofibrillary tangle assembly
negative regulation of neurogenesis
negative regulation of neuron death
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of tau-protein kinase activity
positive regulation of choline O-acetyltransferase activity
positive regulation of early endosome to recycling endosome transport
positive regulation of endocytic recycling
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of protein catabolic process
positive regulation of protein exit from endoplasmic reticulum
positive regulation of protein localization to early endosome
post-Golgi vesicle-mediated transport
protein maturation
protein retention in Golgi apparatus
protein targeting
protein targeting to Golgi
protein targeting to lysosome
receptor-mediated endocytosis
regulation of smooth muscle cell migration
signal transduction - Gene Ontology Molecular Function:
- ADP-ribosylation factor binding
beta-amyloid binding
low-density lipoprotein particle binding
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- early endosome
endoplasmic reticulum
endosome
extracellular exosome
extracellular space
Golgi apparatus
Golgi cisterna
integral component of plasma membrane
low-density lipoprotein particle
membrane
nuclear envelope lumen
recycling endosome
trans-Golgi network - Keywords:
- 3D-structure
Alzheimer disease
Amyloidosis
Cholesterol metabolism
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
LDL
Lipid metabolism
Lipid transport
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Steroid metabolism
Sterol metabolism
Transmembrane
Transmembrane helix
Transport