Names & Taxonomy
- Uniprot ID:
- Q92633
- Entry Name:
- LPAR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
- Gene Names:
- LPAR1 EDG2 LPA1
- Gene Names Primary:
- LPAR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 364
- Sequence:
- MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell surface
Function
- Function:
- Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
- Gene Ontology Go:
- cell surface
dendritic shaft
dendritic spine
endosome
integral component of plasma membrane
neuronal cell body
plasma membrane
G-protein coupled receptor activity
lysophosphatidic acid binding
lysophosphatidic acid receptor activity
activation of MAPK activity
activation of phospholipase C activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
bleb assembly
cell chemotaxis
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
cellular response to oxygen levels
cerebellum development
corpus callosum development
G-protein coupled receptor signaling pathway
myelination
negative regulation of cAMP biosynthetic process
negative regulation of neuron projection development
oligodendrocyte development
optic nerve development
positive regulation of apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of dendritic spine development
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of Rho protein signal transduction
positive regulation of smooth muscle cell chemotaxis
positive regulation of stress fiber assembly
regulation of cell shape - Gene Ontology Biological Process:
- activation of MAPK activity
activation of phospholipase C activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
bleb assembly
cell chemotaxis
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
cellular response to oxygen levels
cerebellum development
corpus callosum development
G-protein coupled receptor signaling pathway
myelination
negative regulation of cAMP biosynthetic process
negative regulation of neuron projection development
oligodendrocyte development
optic nerve development
positive regulation of apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of dendritic spine development
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of Rho protein signal transduction
positive regulation of smooth muscle cell chemotaxis
positive regulation of stress fiber assembly
regulation of cell shape - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
lysophosphatidic acid binding
lysophosphatidic acid receptor activity - Gene Ontology Cellular Component:
- cell surface
dendritic shaft
dendritic spine
endosome
integral component of plasma membrane
neuronal cell body
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Lipid-binding
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix