Names & Taxonomy
- Uniprot ID:
- Q92626
- Entry Name:
- PXDN_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein)
- Gene Names:
- PXDN KIAA0230 MG50 PRG2 VPO VPO1
- Gene Names Primary:
- PXDN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1479
- Sequence:
- MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.
- Catalytic Activity:
- 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.15 mM for H(2)O(2)
- Active Site:
- ACT_SITE 827 827 Proton acceptor.
- Gene Ontology Go:
- endoplasmic reticulum
extracellular exosome
extracellular matrix
extracellular space
proteinaceous extracellular matrix
extracellular matrix structural constituent
heme binding
interleukin-1 receptor antagonist activity
metal ion binding
peroxidase activity
cellular oxidant detoxification
extracellular matrix organization
hydrogen peroxide catabolic process
immune response
negative regulation of cytokine-mediated signaling pathway
oxidation-reduction process
response to oxidative stress - Gene Ontology Biological Process:
- cellular oxidant detoxification
extracellular matrix organization
hydrogen peroxide catabolic process
immune response
negative regulation of cytokine-mediated signaling pathway
oxidation-reduction process
response to oxidative stress - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
heme binding
interleukin-1 receptor antagonist activity
metal ion binding
peroxidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
extracellular exosome
extracellular matrix
extracellular space
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Calcium
Complete proteome
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Heme
Hydrogen peroxide
Immunoglobulin domain
Iron
Leucine-rich repeat
Metal-binding
Oxidoreductase
Peroxidase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal