Names & Taxonomy
- Uniprot ID:
- Q92608
- Entry Name:
- DOCK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Dedicator of cytokinesis protein 2
- Gene Names:
- DOCK2 KIAA0209
- Gene Names Primary:
- DOCK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1830
- Sequence:
- MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endomembrane system
Function
- Function:
- Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
- Gene Ontology Go:
- cytoskeleton
cytosol
endomembrane system
extracellular exosome
membrane
GTPase activator activity
Rac guanyl-nucleotide exchange factor activity
T cell receptor binding
actin cytoskeleton organization
alpha-beta T cell proliferation
chemotaxis
establishment of T cell polarity
immunological synapse formation
macropinocytosis
membrane raft polarization
myeloid dendritic cell activation involved in immune response
negative thymic T cell selection
positive regulation of GTPase activity
positive regulation of phagocytosis
positive thymic T cell selection
regulation of defense response to virus by virus
small GTPase mediated signal transduction
viral process - Gene Ontology Biological Process:
- actin cytoskeleton organization
alpha-beta T cell proliferation
chemotaxis
establishment of T cell polarity
immunological synapse formation
macropinocytosis
membrane raft polarization
myeloid dendritic cell activation involved in immune response
negative thymic T cell selection
positive regulation of GTPase activity
positive regulation of phagocytosis
positive thymic T cell selection
regulation of defense response to virus by virus
small GTPase mediated signal transduction
viral process - Gene Ontology Molecular Function:
- GTPase activator activity
Rac guanyl-nucleotide exchange factor activity
T cell receptor binding - Gene Ontology Cellular Component:
- cytoskeleton
cytosol
endomembrane system
extracellular exosome
membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain - Interacts With:
- Q13137; O95273; P61978; Q6IBN1; Q5VWX1; Q6A162; P60410; P60411; Q9BYR5; P26371; Q9BYQ4; Q9BYQ2; Q99750; Q5JR59; Q7Z3S9; O15162; P63000; P36406