Names & Taxonomy

Uniprot ID:
Q92608
Entry Name:
DOCK2_HUMAN
Status:
reviewed
Protein Names:
Dedicator of cytokinesis protein 2
Gene Names:
DOCK2 KIAA0209
Gene Names Primary:
DOCK2
Organism:
Homo sapiens (Human)

Structure

Length:
1830
Sequence:
MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endomembrane system

Function

Function:
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Gene Ontology Go:
cytoskeleton
cytosol
endomembrane system
extracellular exosome
membrane
GTPase activator activity
Rac guanyl-nucleotide exchange factor activity
T cell receptor binding
actin cytoskeleton organization
alpha-beta T cell proliferation
chemotaxis
establishment of T cell polarity
immunological synapse formation
macropinocytosis
membrane raft polarization
myeloid dendritic cell activation involved in immune response
negative thymic T cell selection
positive regulation of GTPase activity
positive regulation of phagocytosis
positive thymic T cell selection
regulation of defense response to virus by virus
small GTPase mediated signal transduction
viral process
Gene Ontology Biological Process:
actin cytoskeleton organization
alpha-beta T cell proliferation
chemotaxis
establishment of T cell polarity
immunological synapse formation
macropinocytosis
membrane raft polarization
myeloid dendritic cell activation involved in immune response
negative thymic T cell selection
positive regulation of GTPase activity
positive regulation of phagocytosis
positive thymic T cell selection
regulation of defense response to virus by virus
small GTPase mediated signal transduction
viral process
Gene Ontology Molecular Function:
GTPase activator activity
Rac guanyl-nucleotide exchange factor activity
T cell receptor binding
Gene Ontology Cellular Component:
cytoskeleton
cytosol
endomembrane system
extracellular exosome
membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Interacts With:
Q13137; O95273; P61978; Q6IBN1; Q5VWX1; Q6A162; P60410; P60411; Q9BYR5; P26371; Q9BYQ4; Q9BYQ2; Q99750; Q5JR59; Q7Z3S9; O15162; P63000; P36406

Publication

PubMed ID:
9039502 15489334 10559471 12393632 12176041 12432077 15144186 19367720 19369195 19690332 19608861 21269460 24275569 26083206 25944712 21613211