Names & Taxonomy
- Uniprot ID:
- Q92569
- Entry Name:
- P55G_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
- Gene Names:
- PIK3R3
- Gene Names Primary:
- PIK3R3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
- Proteomes:
- UP000005640
Function
- Function:
- Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
- Cross Reference Drug Bank:
- DB01064
- Gene Ontology Go:
- cytosol
phosphatidylinositol 3-kinase complex
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
insulin receptor signaling pathway
phosphatidylinositol biosynthetic process
phosphatidylinositol-3-phosphate biosynthetic process
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
regulation of phosphatidylinositol 3-kinase activity
small molecule metabolic process - Gene Ontology Biological Process:
- insulin receptor signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
regulation of phosphatidylinositol 3-kinase activity
small molecule metabolic process - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity - Gene Ontology Cellular Component:
- cytosol
phosphatidylinositol 3-kinase complex - Keywords:
- Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH2 domain - Interacts With:
- Q8IZP0; P10275; Q66PJ3-4; P22681; P46108; P53672; P00533; P04626; P21860; O43559; Q13480; P08631-2; P42858; P35568; P10721; P08581; Q8TAK6; Q6GQQ9; Q9NPB6-2; Q8N2H9; P42336; Q5SXH7; O60237-2; Q05397; Q96R05; Q9NP31; Q8WXH5; Q99619; P12931; O60636; Q8N6F8; Q8IZQ1