Names & Taxonomy

Uniprot ID:
Q92569
Entry Name:
P55G_HUMAN
Status:
reviewed
Protein Names:
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene Names:
PIK3R3
Gene Names Primary:
PIK3R3
Organism:
Homo sapiens (Human)

Structure

Length:
461
Sequence:
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
Proteomes:
UP000005640

Function

Function:
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Cross Reference Drug Bank:
DB01064
Gene Ontology Go:
cytosol
phosphatidylinositol 3-kinase complex
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
insulin receptor signaling pathway
phosphatidylinositol biosynthetic process
phosphatidylinositol-3-phosphate biosynthetic process
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
regulation of phosphatidylinositol 3-kinase activity
small molecule metabolic process
Gene Ontology Biological Process:
insulin receptor signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
regulation of phosphatidylinositol 3-kinase activity
small molecule metabolic process
Gene Ontology Molecular Function:
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
Gene Ontology Cellular Component:
cytosol
phosphatidylinositol 3-kinase complex
Keywords:
Alternative splicing
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH2 domain
Interacts With:
Q8IZP0; P10275; Q66PJ3-4; P22681; P46108; P53672; P00533; P04626; P21860; O43559; Q13480; P08631-2; P42858; P35568; P10721; P08581; Q8TAK6; Q6GQQ9; Q9NPB6-2; Q8N2H9; P42336; Q5SXH7; O60237-2; Q05397; Q96R05; Q9NP31; Q8WXH5; Q99619; P12931; O60636; Q8N6F8; Q8IZQ1

Publication

PubMed ID:
9524259 14702039 16710414 12470648