Names & Taxonomy
- Uniprot ID:
- Q92536
- Entry Name:
- YLAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
- Gene Names:
- SLC7A6 KIAA0245
- Gene Names Primary:
- SLC7A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 515
- Sequence:
- MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=295 uM for glutamine (in the presence of NaCl)
- Enzyme Regulation:
- ENZYME REGULATION: Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids.
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane
amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity
amino acid transport
blood coagulation
cellular amino acid metabolic process
ion transport
L-alpha-amino acid transmembrane transport
L-amino acid transport
leukocyte migration
protein complex assembly
transmembrane transport
transport - Gene Ontology Biological Process:
- amino acid transport
blood coagulation
cellular amino acid metabolic process
ion transport
L-alpha-amino acid transmembrane transport
L-amino acid transport
leukocyte migration
protein complex assembly
transmembrane transport
transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Amino-acid transport
Antiport
Cell membrane
Complete proteome
Disulfide bond
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport