Names & Taxonomy
- Uniprot ID:
- Q92506
- Entry Name:
- DHB8_HUMAN
- Status:
- reviewed
- Protein Names:
- Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
- Gene Names:
- HSD17B8 FABGL HKE6 RING2 SDR30C1
- Gene Names Primary:
- HSD17B8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.
- Pathway:
- Steroid biosynthesis; estrogen biosynthesis.; Lipid metabolism; fatty acid biosynthesis.
- Catalytic Activity:
- 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.; Testosterone + NAD(+) = androstenedione + NADH.
- Active Site:
- ACT_SITE 169 169 Proton acceptor.
- Gene Ontology Go:
- mitochondrial envelope
mitochondrial matrix
plasma membrane
3-hydroxyacyl-CoA dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
androgen metabolic process
estrogen biosynthetic process
fatty acid biosynthetic process - Gene Ontology Biological Process:
- androgen metabolic process
estrogen biosynthetic process
fatty acid biosynthetic process - Gene Ontology Molecular Function:
- 3-hydroxyacyl-CoA dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
testosterone dehydrogenase (NAD+) activity - Gene Ontology Cellular Component:
- mitochondrial envelope
mitochondrial matrix
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Steroid biosynthesis