Names & Taxonomy

Uniprot ID:
Q8WWX8
Entry Name:
SC5AB_HUMAN
Status:
reviewed
Protein Names:
Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)
Gene Names:
SLC5A11 KST1 SLGTX SMIT2
Gene Names Primary:
SLC5A11
Organism:
Homo sapiens (Human)

Structure

Length:
675
Sequence:
MESGTSSPQPPQLDPLDAFPQKGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVKAILWLCGIQEKGKEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
Gene Ontology Go:
integral component of membrane
plasma membrane
symporter activity
apoptotic process
carbohydrate transport
sodium ion transport
transmembrane transport
Gene Ontology Biological Process:
apoptotic process
carbohydrate transport
sodium ion transport
transmembrane transport
Gene Ontology Molecular Function:
symporter activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Apoptosis
Complete proteome
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Sugar transport
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q8IYQ9

Publication

PubMed ID:
12039040 14702039 15616553 15489334 15172003 18069935