Names & Taxonomy
- Uniprot ID:
- Q8WWL2
- Entry Name:
- SPIR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein spire homolog 2 (Spir-2)
- Gene Names:
- SPIRE2 KIAA1832 SPIR2
- Gene Names Primary:
- SPIRE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 714
- Sequence:
- MARAGSCGGAAAGAGRPEPWELSLEEVLKAYEQPLNEEQAWAVCFQGCRGLRGSPGRRLRDTGDLLLRGDGSVGAREPEAAEPATMVVPLASSEAQTVQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLYIPNTRTLDFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
- Gene Ontology Go:
- cell cortex
cleavage furrow
cytoplasmic vesicle membrane
cytoskeleton
cytosol
perinuclear region of cytoplasm
plasma membrane
actin cytoskeleton organization
actin nucleation
cleavage furrow formation
establishment of meiotic spindle localization
formin-nucleated actin cable assembly
intracellular transport
polar body extrusion after meiotic divisions
protein transport
vesicle-mediated transport - Gene Ontology Biological Process:
- actin cytoskeleton organization
actin nucleation
cleavage furrow formation
establishment of meiotic spindle localization
formin-nucleated actin cable assembly
intracellular transport
polar body extrusion after meiotic divisions
protein transport
vesicle-mediated transport - Gene Ontology Cellular Component:
- cell cortex
cleavage furrow
cytoplasmic vesicle membrane
cytoskeleton
cytosol
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Actin-binding
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Membrane
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transport