Names & Taxonomy

Uniprot ID:
Q8WW43
Entry Name:
APH1B_HUMAN
Status:
reviewed
Protein Names:
Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)
Gene Names:
APH1B PSFL UNQ688/PRO1328
Gene Names Orf:
UNQ688/PRO1328
Gene Names Primary:
APH1B
Organism:
Homo sapiens (Human)

Structure

Length:
257
Sequence:
MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Gene Ontology Go:
integral component of membrane
plasma membrane
transport vesicle
peptidase activity
apoptotic signaling pathway
axon guidance
ephrin receptor signaling pathway
membrane protein intracellular domain proteolysis
neurotrophin TRK receptor signaling pathway
Notch receptor processing
Notch signaling pathway
positive regulation of apoptotic process
positive regulation of catalytic activity
protein processing
Gene Ontology Biological Process:
apoptotic signaling pathway
axon guidance
ephrin receptor signaling pathway
membrane protein intracellular domain proteolysis
neurotrophin TRK receptor signaling pathway
Notch receptor processing
Notch signaling pathway
positive regulation of apoptotic process
positive regulation of catalytic activity
protein processing
Gene Ontology Molecular Function:
peptidase activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
transport vesicle
Keywords:
Alternative splicing
Complete proteome
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
15823552 11230166 12975309 14702039 16572171 15489334 12297508 12740439