Names & Taxonomy
- Uniprot ID:
- Q8WVQ1
- Entry Name:
- CANT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)
- Gene Names:
- CANT1 SHAPY
- Gene Names Primary:
- CANT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 401
- Sequence:
- MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLCSHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
- Catalytic Activity:
- A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cross Reference Drug Bank:
- DB03754
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna membrane
integral component of membrane
calcium ion binding
guanosine-diphosphatase activity
signal transducer activity
uridine-diphosphatase activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteoglycan biosynthetic process
signal transduction - Gene Ontology Biological Process:
- positive regulation of I-kappaB kinase/NF-kappaB signaling
proteoglycan biosynthetic process
signal transduction - Gene Ontology Molecular Function:
- calcium ion binding
guanosine-diphosphatase activity
signal transducer activity
uridine-diphosphatase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna membrane
integral component of membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Disease mutation
Dwarfism
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix