Names & Taxonomy

Uniprot ID:
Q8WVQ1
Entry Name:
CANT1_HUMAN
Status:
reviewed
Protein Names:
Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)
Gene Names:
CANT1 SHAPY
Gene Names Primary:
CANT1
Organism:
Homo sapiens (Human)

Structure

Length:
401
Sequence:
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLCSHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Catalytic Activity:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Cross Reference Drug Bank:
DB03754
Gene Ontology Go:
endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna membrane
integral component of membrane
calcium ion binding
guanosine-diphosphatase activity
signal transducer activity
uridine-diphosphatase activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteoglycan biosynthetic process
signal transduction
Gene Ontology Biological Process:
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteoglycan biosynthetic process
signal transduction
Gene Ontology Molecular Function:
calcium ion binding
guanosine-diphosphatase activity
signal transducer activity
uridine-diphosphatase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
extracellular exosome
Golgi cisterna membrane
integral component of membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Complete proteome
Disease mutation
Dwarfism
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

Publication

PubMed ID:
12234496 12761501 14702039 15489334 12167635 15248776 20425819 22539336 15006348 19853239 21654728 21412251 21037275