Names & Taxonomy
- Uniprot ID:
- Q8WUM9
- Entry Name:
- S20A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)
- Gene Names:
- SLC20A1 GLVR1 PIT1
- Gene Names Primary:
- SLC20A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 679
- Sequence:
- MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=24.1 uM for phosphate
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
high-affinity inorganic phosphate:sodium symporter activity
inorganic phosphate transmembrane transporter activity
receptor activity
signal transducer activity
sodium:inorganic phosphate symporter activity
sodium:phosphate symporter activity
ion transport
phosphate-containing compound metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
transmembrane transport
transport - Gene Ontology Biological Process:
- ion transport
phosphate-containing compound metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
transmembrane transport
transport - Gene Ontology Molecular Function:
- high-affinity inorganic phosphate:sodium symporter activity
inorganic phosphate transmembrane transporter activity
receptor activity
signal transducer activity
sodium:inorganic phosphate symporter activity
sodium:phosphate symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Complete proteome
Membrane
Phosphate transport
Phosphoprotein
Receptor
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport