Names & Taxonomy
- Uniprot ID:
- Q8TEQ8
- Entry Name:
- PIGO_HUMAN
- Status:
- reviewed
- Protein Names:
- GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O)
- Gene Names:
- PIGO UNQ632/PRO1249
- Gene Names Orf:
- UNQ632/PRO1249
- Gene Names Primary:
- PIGO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1089
- Sequence:
- MQKASVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVVLVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEIQPHHARLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPFCPLLLTPVAWGLVGAIAYAGLLGTIELKLDLVLLGAVAAVSSFLPFLWKAWAGWGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSATTNPPRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGGRAKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPPRLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPPGNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQLFLAQQR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity).
- Pathway:
- Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mannose-ethanolamine phosphotransferase activity
C-terminal protein lipidation
cellular protein metabolic process
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Biological Process:
- cellular protein metabolic process
C-terminal protein lipidation
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Molecular Function:
- mannose-ethanolamine phosphotransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Endoplasmic reticulum
GPI-anchor biosynthesis
Glycoprotein
Membrane
Mental retardation
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix