Names & Taxonomy
- Uniprot ID:
- Q8TED4
- Entry Name:
- G6PT3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2)
- Gene Names:
- SLC37A2
- Gene Names Primary:
- SLC37A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKPINDTHSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGEPAENQDNPEDPGNSPCSIRESGLETVAKCSKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKVSLSRGSGYKEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by vanadate but not by chlorogenic acid.
- Gene Ontology Go:
- extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of membrane
glucose 6-phosphate:inorganic phosphate antiporter activity
transmembrane transporter activity
anion transport
carbohydrate transport
glucose-6-phosphate transport
phosphate ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- anion transport
carbohydrate transport
glucose-6-phosphate transport
phosphate ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- glucose 6-phosphate:inorganic phosphate antiporter activity
transmembrane transporter activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Antiport
Complete proteome
Endoplasmic reticulum
Glycoprotein
Membrane
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport