Names & Taxonomy

Uniprot ID:
Q8TED4
Entry Name:
G6PT3_HUMAN
Status:
reviewed
Protein Names:
Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2)
Gene Names:
SLC37A2
Gene Names Primary:
SLC37A2
Organism:
Homo sapiens (Human)

Structure

Length:
501
Sequence:
MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKPINDTHSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGEPAENQDNPEDPGNSPCSIRESGLETVAKCSKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKVSLSRGSGYKEI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by vanadate but not by chlorogenic acid.
Gene Ontology Go:
extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of membrane
glucose 6-phosphate:inorganic phosphate antiporter activity
transmembrane transporter activity
anion transport
carbohydrate transport
glucose-6-phosphate transport
phosphate ion transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
anion transport
carbohydrate transport
glucose-6-phosphate transport
phosphate ion transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
glucose 6-phosphate:inorganic phosphate antiporter activity
transmembrane transporter activity
Gene Ontology Cellular Component:
extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of membrane
Keywords:
Alternative splicing
Antiport
Complete proteome
Endoplasmic reticulum
Glycoprotein
Membrane
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12693554 14702039 15489334 21949678