Names & Taxonomy

Uniprot ID:
Q8TE54
Entry Name:
S26A7_HUMAN
Status:
reviewed
Protein Names:
Anion exchange transporter (Solute carrier family 26 member 7)
Gene Names:
SLC26A7 SUT2
Gene Names Primary:
SLC26A7
Organism:
Homo sapiens (Human)

Structure

Length:
656
Sequence:
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Recycling endosome membrane

Function

Function:
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.
Gene Ontology Go:
basolateral plasma membrane
cytoplasm
endosome
integral component of plasma membrane
plasma membrane
recycling endosome membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
gastric acid secretion
ion transport
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sulfate transmembrane transport
sulfate transport
transmembrane transport
Gene Ontology Biological Process:
anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
gastric acid secretion
ion transport
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sulfate transmembrane transport
sulfate transport
transmembrane transport
Gene Ontology Molecular Function:
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
cytoplasm
endosome
integral component of plasma membrane
plasma membrane
recycling endosome membrane
Keywords:
Alternative splicing
Anion exchange
Complete proteome
Endosome
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11829495 11834742 15489334 12736153 15956810 16524946 17504921