Names & Taxonomy

Uniprot ID:
Q8TDS4
Entry Name:
HCAR2_HUMAN
Status:
reviewed
Protein Names:
Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
Gene Names:
HCAR2 GPR109A HCA2 HM74A NIACR1
Gene Names Primary:
HCAR2
Organism:
Homo sapiens (Human)

Structure

Length:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Cross Reference Drug Bank:
DB00627
Gene Ontology Go:
cell junction
integral component of membrane
plasma membrane
nicotinic acid receptor activity
negative regulation of lipid catabolic process
neutrophil apoptotic process
positive regulation of adiponectin secretion
positive regulation of neutrophil apoptotic process
Gene Ontology Biological Process:
negative regulation of lipid catabolic process
neutrophil apoptotic process
positive regulation of adiponectin secretion
positive regulation of neutrophil apoptotic process
Gene Ontology Molecular Function:
nicotinic acid receptor activity
Gene Ontology Cellular Component:
cell junction
integral component of membrane
plasma membrane
Keywords:
Apoptosis
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
12522134 12044878 15489334 17932499 21454438